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23-Nov-2017 23:41

'Another posted: 'Uhhh, does anyone else hear "f*** you little bear," on the M&S Christmas ad? 'A further tweet read: 'HAHA when he said thank you little bear I heard f*** you little bear, cant have been the only one'.

The advert, by Grey London, begins with Paddington - voiced by Ben Wishaw, who reprises his role as the duffle coat-wearing bear - waking up from a dream about marmalade after he hears someone on the roof on Christmas Eve.

Chromogranin A (Cg A) is the major soluble protein in the core of catecholamine-storage vesicles and is released with catecholamines by exocytosis from the chromaffin cells of the adrenal medulla and from sympathetic axons.

Cg A is found in secretory vesicles throughout the neuroendocrine system and may exemplify a prototypical prohormone precursor (), which inhibits parathyroid hormone release.

As he leans in to give Paddington a grateful embrace, he whispers 'thank you little bear' in his ear.

However, hundreds of people watching the advert, when it aired for the first time on Tuesday, heard something rather different.

Naturally, the burglar eventually sees the error of his ways as the bear from deepest, darkest Peru shows the thief how excited the family are as they open their presents.

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in: JCI | Pub Med | Google Scholar Department of Vascular Biology, The Scripps Research Institute, La Jolla, California, USA Address correspondence to: Robert J. Parmer, Nephrology/Hypertension (9111-H), University of California, San Diego, 3350 La Jolla Village Drive, San Diego, California 92161, USA. We show here that the major fibrinolytic enzyme, plasmin, can cleave Cg A to form a series of large fragments as well as small trichloroacetic acid-soluble peptides.

Department of Vascular Biology, The Scripps Research Institute, La Jolla, California, USA Address correspondence to: Robert J. Parmer, Nephrology/Hypertension (9111-H), University of California, San Diego, 3350 La Jolla Village Drive, San Diego, California 92161, USA. Interactions between Cg A and plasmin(ogen) define a previously unrecognized autocrine/paracrine system that may have a dramatic impact upon catecholamine secretion.

Parmer, Nephrology/Hypertension (9111-H), University of California, San Diego, 3350 La Jolla Village Drive, San Diego, California 92161, USA. The mechanisms and specific proteases involved in the processing of prohormone precursors in the neuroendocrine system are not fully established.

However, the protease(s) responsible for generating this activity in the chromaffin cell environment have not been identified () and is present in the extracellular environment of the chromaffin cell, we examined whether plasmin might participate in the processing of Cg A.

Early work in the 1950s suggested a role for the plasminogen/plasmin system in the processing and degradation of bioactive peptides, including ACTH, growth hormone, and glucagon ().It will also air before every screening of Paddington 2, which hits cinemas from Friday.